SPIRAMYCIN: A REAPPRAISAL OF ITS ANTIBACTERIAL ACTIVITY
نویسندگان
چکیده
منابع مشابه
Synthesis and in vitro antibacterial activity of catechol-spiramycin conjugates.
The first synthesis of siderophore conjugates of two macrolide antibiotics, spiramycin 1 and neospiramycin 2, which are unable to penetrate the outer membrane of gram-negative bacteria are described. These novel conjugates were prepared by regioselective acylation of a hydroxyl function of 1 and 2 with a dihydroxybenzoic Fe(III) complexing ligand linked via a carboxyl group containing spacer to...
متن کاملAntibacterial activity of Pentanema divaricata ethanol extract and its fractions
In the past few years, the world has taken a new view to herbal remedies and their applications and many researchers in various fields of medicine are studying this subject. In our program searching for antibacterial agents we have selected an extract prepared from the Pentanema divaricata. No report on the antibacterial activity of this species has been published in literature. Pentanema divar...
متن کاملAntibacterial activity of Pentanema divaricata ethanol extract and its fractions
In the past few years, the world has taken a new view to herbal remedies and their applications and many researchers in various fields of medicine are studying this subject. In our program searching for antibacterial agents we have selected an extract prepared from the Pentanema divaricata. No report on the antibacterial activity of this species has been published in literature. Pentanema divar...
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The in-vitro action of the sulphamethoxazole/trimethoprim combination (cotrimoxazole) against coliforms, Proteus spp, and Staphylococcus aureus was re-examined. In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to t...
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OBJECTIVES Previous studies have shown that metronidazole, alone or in combination with spiramycin (250 mg/1 500 000 units, three times/day), is an effective treatment for active periodontitis, although the dose of metronidazole currently used (750 mg/day) could provide concentrations in gingival crevice fluid that are too low for the MICs of the involved pathogens. This study tested the in viv...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1962
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1962.tb01430.x